The Titan adapter # T4845900 will work with the factory integrated brake controller in your 2008 Ford F-250 as long as you are using the BrakeRite SD system, # T4835700, and disc brakes. Or use BrakeRite EHB # T4813100 with the same adapter for disc brakes.
For drum brakes use BrakeRite EHB, # T4822500, which requires a different adapter, # T4846000.
I have included links to a couple of helpful articles on the parts needed to add electric over hydraulic disc or drum brakes to a trailer.